On 4 and 5 March 2009, in Rome, the Research Division of the NATO Defence College organized an international seminar on the theme ‘Towards a new US foreign policy in the Middle East?’ The main conclusions of the seminar, held under Chatham House rules, can be summed up as: a return by the United States to pragmatism and rationality; a genuine spirit of openness—tempered by prudence—in the Arab world; a growing and potentially destabilising uncertainty on Israel’s part.